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While liraglutide also showed cardiovascular benefit (13% reduction in the LEADER trial), semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity

Nomenclature of targets and ligands Key protein targets and ligands in this article are hyperlinked to corresponding entries in the IUPHAR/BPS Guide to PHARMACOLOGY ( and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/20 (Alexander, Christopoulos, et al., 2019

[DOI] [PubMed] [Google Scholar] [66].Watson E, Jonker DM, Jacobsen LV, Ingwersen SH, Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide, Journal of clinical pharmacology, 50 (2010) 886894

Instead, it reveals inherited predispositions in peptide signaling genes that may explain baseline metabolic traits

doi:10.1210/jcem.76.4.8473405 31

Yet, environmental, developmental, genetic, and epigenetic factors are seemingly involved 5