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Unnikrishnan, CEO and Chief of Endocrinology at Chellaram Diabetes Institute, Pune, said, Oral semaglutide has shown it can reduce the risk of major adverse cardiovascular events (MACE), regardless of whether participants were already using sodium-glucose cotransporter-2 inhibitors (SGLT2i)

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Our studies revealed key signaling mechanisms underlying the role of GPR17 in regulating GLP-1 secretion and suggest future opportunities for pharmacologically targeting GPR17 with inverse agonists to maximize GLP-1 secretion ![Graphical Abstract][1] Graphical Abstract ### Competing Interest Statement The authors have declared no competing interest