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The gut-brain axis: These drugs interact with the area postrema in the brainstem (the region that controls the vomiting reflex) to reduce appetite, which can sometimes trigger nausea

Preclinical studies suggest GLP-1 receptor signaling can modulate sympathetic outflow and peripheral thermoregulatory responses, although direct human evidence remains limited

A newer dual GIP/GLP-1 agent also targets the GIP pathway for additional metabolic effects

low-density lipoprotein (LDL) cholesterol, 0.27 mmol/l

B12 deficiency also causes fatigue, which is one reason Strive glycine/B12 formulation exists

Magnesium, potassium, and calcium imbalances have all been associated with muscle cramping and weakness