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Months 6-12: Approaching or reaching goal weight (30-50+ pounds total), metabolic improvements sustained, transition to maintenance planning, established healthier habits

351 In the process of ferroptosis, cells are affected by oxidative stress and lipid peroxidation, resulting in the rupture of cell membranes and cell death, which is manifested mainly by the reduction in GPX4, the core enzyme of the antioxidant system (glutathione system), and the high expression of the lipid peroxidation marker 4-HNE

13 Semaglutide, another GLP-1 agonist already approved for type 2 diabetes treatment, is also in ongoing trials for obesity treatment in patients without diabetes 14 and may provide a greater weight loss benefit than liraglutide

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