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Because amylin and GLP-1 act on distinct but potentially complementary satiety pathways, combining a compound such as cagrilintide with a GLP-1 agonist is studied as a way to probe how these routes interact at a signalling level

found that liraglutide treatment led to reductions in FBG and leptin, improving IR and demonstrating favorable metabolic effects in women with PCOS 52 (Table 3)

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This critical information helps identify potential drug interactions with GLP-1 medications, contraindications requiring dosage adjustments, or medications affecting gastrointestinal motility that might compound side effects when combined with appetite-suppressing therapies