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Data from the large cardiovascular safety studies with DPP-4 inhibitors (see section below) did not show a respective signal

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This inflammatory cascade exacerbates coronary microvascular dysfunction, a key feature of HFpEF, and elevates plasma volume and cardiac workload [28]

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Instead, focus on integrating more whole foods that promote digestive health and support regular bowel movements

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Eur J Heart Fail 24(10):19061914

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