side effects of glp-1 agonists Table 2 from Optimizing Outcomes for long term effects of glp-1

68 In contrast, other large-scale population-based studies have failed to demonstrate a significant increase in intestinal obstruction risk when GLP-1 RAs were compared with SGLT-2 inhibitors

In theory, the transfer to human milk of GLP-1 agonists may be low, as they are large peptide molecules ( Supplement 3 )

Chalmanov V, Vurbanova M

While some clinical investigations indicate that combination therapy primarily exhibits gastrointestinal-related adverse effects without significant escalation in overall adverse event incidence 14,15 , contrasting expert opinions advocate for metformin dose reduction or discontinuation during GLP-1 receptor agonist treatment 16

We included 26 records regarding the safety of GLP-1 agonists during pregnancy and/or lactation ( Supplement 2 , 3 ), and 16 records regarding the safety of SGLT2 inhibitors during pregnancy and/or lactation ( Supplement 2 , 3 )

J.DeaconC