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These effects may be particularly relevant in patients with comorbid obesity and obstructive sleep apnea (OSA), conditions frequently co-occurring with SUDs such as alcoholism and opioid dependence [36,37]
Jacobsen LV, Vouis J, Hindsberger C, Zdravkovic M
The reduced incretin effect of GIP in diabetic subjects may be due to the down-regulation of GIP receptor expression, which has been found in pancreatic islets of diabetic Zucker rats and reverted following correction of hyperglycemia [35]
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Once the leader in GLP-1 medications, Novo Nordisk has lost ground to Eli Lilly, which now captures more new prescriptions for obesity medications
Fatigue affects some patients, particularly in the early weeks
