tirzepatide glp-1 side effects Comparative safety and of semaglutide and tirzepatide: Implications for clinical decision-making in obesity management are side effects worse on

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Knop: Back in 2009, in my effort to better understand how the gut hormone glucagon-like peptide 1 (GLP-1) is secreted, I read TGR5-mediated bile acid sensing controls glucose homeostasis (Thomas, et al.), which described how bile acids may stimulate the secretion of this glucose-lowering and satiety-promoting hormone

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In routine care, patients often use lower doses than those tested in trials and may discontinue treatment early, making overall weight loss outcomes typically smaller than those observed in RCTs