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10.1177/0022034513500306 12 BuckleyS

6 However, GLP-1 receptor agonists and gut-derived GLP-1 do not cross the bloodbrain barrier and cannot access GLP-1 receptors in the brain parenchyma, which can only be accessed by brain (pre-proglucagon neuron)-derived GLP-1

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This is typically a last resort as it is an invasive surgery, and it is reserved only for those whose obesity is already causing them adverse health effects

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The study also reported shifts in numerous other bacterial taxa, including reductions in some Blautia, Roseburia, and Veillonella species among red meat consumers, as well as increases in Collinsella aerofaciens