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GLP-1 medications can worsen existing GERD in some people, partly because slowed gastric emptying means more time for acid to reflux

GLP-1RA intervention was associated with increased dizziness when compared to those given metformin or placebo (OR = 5.58

Since GLP-1 antagonists slow digestion, they may worsen certain gastrointestinal conditions

The key is balancing blood sugar, hormones, and inflammation , while protecting lean muscle

These agents likely combine reduced energy intake with changes in substrate metabolism, insulin secretion, and energy expenditure

Additionally, a multi-country study found substantial demand for GLP-1 medications among people without medical indications, highlighting the evolving landscape of body image and obesity treatment (Jensen et al., 2025)