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doi:10.1016/j.cmet.2017.07.011 52

Nat Rev Endocrinol 21 , 521522 (2025)

Nalmefene is recommended (TA325) for reducing alcohol consumption in people with alcohol dependence who have a high drinking risk level (more than 60g/7.5 units daily for men, or more than 40g/5 units daily for women) without physical withdrawal symptoms and not requiring immediate detoxification, specifically when used alongside continuous psychosocial support

For weight loss injections, this could mean using a drug approved for diabetes for weight management purposes, or using a drug at a dosage not specifically listed for weight loss

Duration of effect : Dementia develops over many years (often decades)