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Los pacientes en tratamiento con tirzepatida, especialmente aquellos con factores de riesgo adicionales, deben estar atentos a los siguientes signos y sntomas: Manifestaciones hematolgicas: Fatiga persistente y debilidad generalizada, a menudo el sntoma ms temprano Palidez de piel y mucosas debido a anemia megaloblstica Disnea (dificultad para respirar) con esfuerzos mnimos Palpitaciones o taquicardia compensatoria Manifestaciones neurolgicas: Parestesias (hormigueo o entumecimiento) en manos y pies, tpicamente simtricas Alteraciones en la marcha o inestabilidad, debido a degeneracin combinada subaguda de la mdula espinal Prdida de sensibilidad vibratoria y propioceptiva Debilidad muscular progresiva En casos severos, deterioro cognitivo, confusin o cambios en la memoria Otras manifestaciones: Glositis (lengua inflamada, lisa y dolorosa) Cambios en el estado de nimo, incluyendo depresin o irritabilidad Visin borrosa en casos raros (neuropata ptica) Es crucial reconocer que las manifestaciones neurolgicas pueden ocurrir incluso en ausencia de anemia , y si no se tratan, pueden volverse irreversibles

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Long-term risks of Trulicity include the potential worsening of or new onset kidney damage and severe digestive problems such as gastroparesis or ileus

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Physiology & Behavior, 297, 114953

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