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Maintain adequate hydration, especially during hot weather or illness

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Common GLP-1 Side Effects According to clinical literature and FDA labeling for approved GLP-1 medications, commonly reported side effects include nausea (especially when starting or after dose increases), vomiting, diarrhea, constipation, abdominal discomfort, decreased appetite, fatigue, and injection site reactions (for injectables)

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The 2024 FDA shortage resolution In 2024, the FDA declared the semaglutide shortage resolved

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The SURPASS trials, sponsored by pharmaceutical manufacturer Eli Lilly, assessed Mounjaro (tirzepatide) in people with type 2 diabetes and obesity

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GLP-1 medications work by mimicking natural incretin hormones to improve blood glucose control and reduce appetite Common side effects are gastrointestinal (nausea, vomiting, diarrhoea) rather than fluid retention Unlike thiazolidinediones, GLP-1 agonists are not associated with oedema as a recognised adverse effect Any unexplained swelling whilst taking GLP-1 medications requires medical assessment to exclude other causes Dehydration from gastrointestinal side effects is more common than fluid retention with GLP-1 therapy Table of Contents What Are GLP-1 Medications and How Do They Work

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There has not been any specific funding for preparing the present manuscript

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