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This happens because your body adapts to chronic stimulation by reducing receptor density or altering downstream signaling pathways

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Avoid the cycle of jumping too high too fast, feeling unwell, and pausing therapy

Patients who are overweight and have weight-related health concerns may also be considered for treatment depending on provider assessment

Key takeaways Without insurance, the cost of semaglutide can range from $149 (for the lowest dose of the Wegovy pill) to nearly $1,870 (for brand-name versions) per month

Continuing treatment beyond 12 weeks allowed most people to reach clinically significant weight loss regardless of early response