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How the Brain Talks It turns on GLP-1 receptors in the brain, mainly in the hypothalamus, which makes you feel fuller and less hungry

GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation

Review Article: Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity Background More than 19 years after the first GLP1RA was introduced for type 2 diabetes and 10 years after its approval for obesity, innovations are expanding the use of GLP-1 medicines for metabolic disorders

95% CI 0.66 1.14

Before this can happen, the pill will need to be evaluated by the National Institute for Health and Care Excellence

doi:10.6065/apem.2017.22.1.15 Doyle ME, Egan JM