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Replication in multisite RCTs with rigorous assessment of craving, substance use and relapse risk will be essential to determine the clinical utility of GLP1RAs in addiction medicine

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GLP-1 (glucagon-like peptide-1) is a hormone that plays roles in appetite suppression and glucose regulation

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Paid subscribers: In the paid section, I go deeper into what food noise actually is, how GLP-1s act on metabolic and reward circuits in the brain, and why this explains both their effectivenessand why weight often returns when theyre stopped

There are many ways to fuel the body with nutrient-rich foods that will not cause weight gain