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Prescription options may include: Mounjaro (tirzepatide) Zepbound (tirzepatide) Wegovy (semaglutide) Ozempic (semaglutide) Medication selection, dosing, and monitoring are determined by licensed healthcare providers based on medical necessity, safety considerations, and FDA-approved indications

However, they strongly advise that these compounded drugs are not substitutes for approved, FDA-reviewed products and should be used only under medical supervision

A Lilly spokesperson said in an emailed statement that the FDAs post-approval requirements are routine and consistent with the agencys approach to ongoing safety reviews of newly approved drugs

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Apostol Apostolov: Conceptualization, Writingreview & editing

In addition, pharmacological activation of central GLP-1 receptor (GLP-1R) signaling expressed by serotonergic neurons [110112] augments the activity of thermogenic adipose tissue and enhances the utilization of circulating glucose and triglycerides [113, 114]