glp-1 small molecule agonist PDB-101: of the Month: Receptor Agonists Binding sites and design strategies

Glucagon-like peptide-1 inhibits prandial gastrointestinal motility through myenteric neuronal mechanisms in humans

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Tomovic K., Lazarevic J., Kocic G., Deljanin-Ilic M., Anderluh M., Smelcerovic A

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Subsequently, PKA activity can augment the release of neurotransmitters into the synapse, facilitating long-term potentiation (LTP) and promoting cAMP-response element binding protein (CREB) phosphorylation, supporting cell growth/survival as well as synaptic plasticity [31, 33]

GLP-1RAs also shift microbiota composition, increasing beneficial SCFA-producing taxa such as Akkermansia and Bifidobacterium , which may alleviate systemic inflammation (106108)