retatrutide mechanism triple agonist glp-1 gip glucagon receptor LY3437943, a novel glucagon, GIP, and for glycemic control and weight loss: From discovery to clinical proof of concept Retatrutide, a GIP, GLP-1 and

[DOI] [PubMed] [Google Scholar] 407.Runge S., Thogersen H., Madsen K., Lau J., Rudolph R

While GLP-1s are effective for weight loss, they are not clinically appropriate for everyone

The Lancet

Zhao Q, Xu H, Zhang L, Liu L, Wang L

Peripheral but not central administration of GLP-1 fails to inhibit angiotensin (ANG) II-induced drinking in rats that have been treated with monosodium glutamate (MSG) to induce damage of the ARC and the sensory circumventricular organs, suggesting that peripherally administered GLP-1 effects drinking behavior via CNS-dependent mechanisms [760]

In 14 patients with coronary artery disease and good LV function, intravenous GLP-1 infusion improved global and regional wall LV function on dobutamine stress echocardiography compared with control [92]