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Description
The main difference between semaglutide and tirzepatide is that the latter mimics two gut hormones not just one GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)
If improvement is minimal, add bismuth subsalicylate (Pepto-Bismol) after meals and consider discussing slower dose titration with your provider
In some cases, tiredness may also be related to an underlying medical condition rather than the drug itself

Should I stop my medication if I feel too tired

Gut 58 , 10911103 (2009)
This is known as orthostatic intolerance and involves abnormal blood pressure and heart rate
