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Lupus itself also increases the risk of cardiovascular disease

These effects were achieved through direct vasoactive and anti-inflammatory effects of exendin, as well as modulation of the pulmonary artery smooth muscle cell phenotype

Verdict : Cautious (legacy use only

Palazzo et al., 2007

Exxuas label includes a boxed warning for suicidal thoughts and behaviors in children and young adults, for whom the drug is not approved
