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Role of intra-islet paracrine signaling in the effects of pharmaceutical targeting of GLP-1 As current therapies focusing on increasing insulin sensitivity and/or insulin secretion fail to cure diabetes, one potentially underappreciated target for diabetes treatment is the alpha-cell

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These mice had impaired oral glucose tolerance (Song et al., 2019), but cumulative food intake and bodyweight were unaffected (Panaro et al., 2020), although neither gastric emptying nor satiation were explicitly tested

[DOI] [PubMed] [Google Scholar] 11.Li L, El-Kholy W, Rhodes CJ, Brubaker PL

While GLP-1 medications improve glycemic control in patients with type 2 diabetes, lower blood glucose levelsparticularly if they drop too quicklycan sometimes be associated with feeling cold

"Well, how do we get them in our body