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Semaglutide is an FDA-approved medication initially developed to treat type 2 diabetes

Patients with genetic variants that confer higher GLP-1 receptor sensitivity may experience amplified medication effects, including more pronounced nausea when alcohol is added

Tirzepatide comes in a pen device that does not allow for custom dosing in the same way

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Only 2 of those RCTs (Nicholson 2000 and Treanor 2000) were published in peer-reviewed journals

The activation of JAK2/STAT3 [163] induces the expression of the pro-fibrotic mediators TGF-1, collagen type I, IL-1, IL-6, and CCL2 particularly in Kupffer cells and sinusoidal endothelial cells [164, 165] (Fig