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Leptin also enhances ECM accumulation by regulating MMPs/TIMPs system, through the activation of MAPKs such as ERK and p38 pathways that lead to the suppression of collagen-degrading enzymes MMP-1 expression while upregulation of its inhibitor TIMP-1 [171, 172]

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Based on these Phase 2 results, Eli Lilly initiated a comprehensive Phase 3 program spanning multiple trials in both obesity (ATTAIN series) and type 2 diabetes (ACHIEVE series)

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