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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

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Metformin, the most widely prescribed diabetes medication, does not directly increase UTI risk

LIRA a dosis de 1,8mg diarios induce mejora de la enfermedad esteatsica heptica asociada a disfuncin metablica (MASLD) con resolucin de esteatohepatitis en el 39% de los casos, mientras que la fibrosis progres en el 9% de los pacientes, frente al 36% tratados con placebo29 (fig

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