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Kaptiza C, Nosek L, Jensen L, Hartvig H, Jensen CB, Flint A
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CLINICAL APPLICATION OF GLP-1 IN LIPID METABOLISM AND ADIPOSE-RELATED DISORDERS Effects of glp-/glucose-dependent insulinotropic peptide dual agonists on lipid metabolism GLP-/glucose-dependent insulinotropic peptide (GIP) dual agonists are a new type of oral hypoglycemic drug, which can activate both GLP-1 and GIP incretin at the same time, thereby exerting a more comprehensive blood glucose control effect [125]

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However, some patients notice their appetite-suppressing benefits seem to plateau after 36 months of consistent use, raising concerns about whether the medication truly stops working or whether their body has simply adapted to the dose

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