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Poorly controlled blood sugar is the most significant risk factor, as persistently elevated glucose levels directly injure peripheral nerves [70]

10.2169/internalmedicine.51.7876 62 NaranjoC

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Comparative work with semaglutide (GLP-1R only) and tirzepatide (GIPR + GLP-1R) provides the field with a comprehensive map of how incremental receptor engagement reshapes downstream pharmacology across pancreatic, hepatic, adipose, and central nervous system tissues

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Standing Out in a Crowded Weight Loss Market The approval comes at a time of unprecedented public interest in GLP-1 medications