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Although it is known that long-acting GLP-1 receptor agonists have diminishing effects on gastric emptying over time, subcutaneous semaglutide is reported to continue to delay gastric emptying, implying that it is less affected by tachyphylaxis [22]

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Retatrutide does not directly alter circadian rhythm, but the changes in eating patterns and metabolic activity can indirectly affect sleep-wake timing

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However, no significant difference in eGFR was found in patients treated with liraglutide 3.0 mg and semaglutide 2.4 mg in post-hoc analyses of the SCALE Obesity and Prediabetes, SCALE Diabetes and STEP 13 trials 79,81

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TriNetX has been widely used for real-world evidence studies across multiple medical disciplines and supports pharmacoepidemiologic analyses using methods such as propensity score matching and time-to-event modelling ( Study design and target trial emulation We designed this study to emulate a hypothetical target trial ( Supplementary Table 1 )

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