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However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment

Principally, there was no way to verify whether medication orders lined up with patients actually taking the medication
Bain SC, Mosenzon O, Arechavaleta R, et al

Estudios clnicos: Informacin sobre la eficacia y seguridad clnica: Tanto la mejora del control glucmico como la reduccin de morbilidad y mortalidad cardiovascular son una parte integral del tratamiento de la diabetes tipo 2
