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In mice, the enzyme neprilysin additionally rapidly degrades the metabolites, making GLP-1 difficult to measure in this species [189]

Prior authorization is a more restrictive type of cost-management strategy, in that every prescription will be stopped at point of sale and may require a physician to confirm that the drug is being prescribed for those with diabetes or possibly provide documentation of medical records showing a blood glycemic level test (e.g., A1C) that confirms diabetes