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Mazdutide overall appears to achieve superior weight loss, in shorter periods of times compared to GLP1R agonists

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This increased activity is strongly associated with HbA1c, the level reflecting average blood sugar over weeks

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He noted that the 4 mg dose achieved "nearly 20% weight loss with one escalation step," while the 12 mg dose "delivered a level of weight loss long associated with bariatric surgery." He added that retatrutide could support a more patient-centric approach to treating obesity

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