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The FNDC5 cleavage and secretion process itself remains incompletely understood: the efficiency of irisin shedding in humans appears lower than in rodents, partly explaining why rodent exercise phenotypes driven by irisin overexpression have been difficult to reproduce cleanly in human studies

So let us look at what the clinical trials actually show

They: Slow digestion Increase satiety Regulate blood sugar Emerging research shows they also affect the brains reward system

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For blood glucose control, the onset of action varies by medication

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