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This information should be interpreted with a qualified provider to potentially inform which formulation or dose tier may fit your metabolic profile, reducing costly trial-and-error cycles

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Within a physician-supervised programme, both medications have well-established safety profiles

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FIGURE 3 5 GLP-2 Like GLP-1, GLP-2 is secreted by L-cells in the small and large intestine after nutritional intake, and GLP-2 secretion was not as high after ingestion of a carbohydrate-rich meal as it was after ingestion of protein and fat (Raben et al., 2003)

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"A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3) - Lilly Clinical Trials"

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Tirzepatide is also contraindicated in individuals with a history of multiple endocrine neoplasia syndrome Type-2 (MEN 2)

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53 These findings are supported by a 2025 meta-analysis of 30 RCTs including over 37,000 individuals with overweight or obesity

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