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In fact, it is reported (Underwood et al., 2010) that exendin-4 (939) binds strongly (EC 50 5 pM, IC 50 0.76 nM) to wild-type GLP-1R than the native GLP-1 (EC 50 11 pM, IC 50 1 nM)

*Disclaimer: Results may vary from person to person depending on individual engagement and commitment to the programme

Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal Axis in man

This is difficult to accomplish with weekly subcutaneous injection, where the peptide is always present at relatively steady-state levels

Extreme heat can damage the medication

Weight loss or improved weight management