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Instead, the FDA cited 'deficiencies in the manufacturing and chemistry documentation (CMC).' This means the issues are related to the paperwork and processes around how the drug is made, rather than how well it works or its side effects in patients

Journal of Endocrine Research, 21(1), 3544

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This is especially relevant if you are taking supplements alongside tirzepatide or combining it with other medications like metformin or berberine

As fat mass decreases due to weight loss, the secretion of adipokines changes, which can impact hormone levels involved in the menstrual cycle, such as estrogen and progesterone