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doi: 10.1186/s12933-019-0942-x 102 LamCSPRamasundarahettigeCBranchKRHSattarNRosenstockJPratleyRet al

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And research published in JCI Insight reveals something fascinating: tirzepatide shows an "imbalanced" affinity, engaging GIP receptors more strongly than GLP-1 receptors while producing biased signaling at the GLP-1 receptor that favors cAMP generation over beta-arrestin recruitment

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