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AMPK activation), and direct pharmacological conflicts haven't been documented

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Consistent hydration helps maintain proper methotrexate clearance and reduces toxicity risk

Restricting carbohydrate intake reduces blood glucose and insulin levels and increases fat metabolism, resulting in increased levels of byproducts known as ketone bodies

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5b, Discussion S4 ) that enables calculation of additional PK parameters, including the peak-to-trough ratio, which reflects therapeutic stability by comparing C max to the steady-state plateau