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Basal insulin analogues were designed with prolonged duration of action and reduced pharmacodynamic variability compared with protamine-based (NPH) human insulin, while rapid-acting analogues were introduced with quicker onset and shorter duration than short-acting (regular) human insulin, resulting in reduced early postprandial hyperglycaemia and less later hypoglycaemia several hours after the meal [3]

doi:10.1016/j.yjmcc.2015.09.018 84

Compare and contrast the glucagon-like peptide-1 receptor agonists (GLP1RAs) [Updated 2024 Feb 25]

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Edgar, R., Domrachev, M