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Earlier this year, Veru reported that stair climb power declined by 10% for 42% of older adults with just 16 week on semaglutide in its Phase 2b study an androgen receptor agonist (enobosarm)

This warning also includes concerns about hypercalcemia

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Therefore, GLP-1 has been extensively studied as a possible treatment of type 2 diabetes, and GLP-1 analogues and DPP-4 inhibitors are now widely in clinical use in these patients [711]

For one, you cant use them to jump-start your weight loss, and then attempt to maintain your weight on your own without making necessary lifestyle changes