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Participants got two liver biopsies to help evaluate the effects of semaglutide

Ozempic (semaglutide) and Mounjaro (tirzepatide) are FDA-approved for type 2 diabetes management but may be prescribed off-label for weight management at a clinician's discretion

Intracranial electrodes were implanted 8 days before PTZ injection

Disrupted sleep impairs the hormonal regulation of appetite, increasing hunger and reducing satiety

The other long-term concern is muscle loss (sarcopenia), which is not drug specific it accompanies any form of rapid weight reduction, and needs preventive measures like enhanced protein intake and strength training to be instituted from the beginning

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