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One key difference between the two is how they work: Tirzepatide is a dual agonist, which means it affects two different pathways, GLP-1 and GIP, whereas semaglutide only affects GLP-1

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Like all class B GPCRs, GLP-1R possesses an N-terminal ECD of 100150 residues connected to an integral TM domain (7TM) that is typical of all GPCRs, having seven -helices (TM1TM7) separated by ICL1ICL3 and ECL1ECL3 (Palczewski et al., 2000