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Standardization of clinical trial designs and validation of noninvasive technologies will greatly accelerate progress and are likely to emerge within 5 years, in part through all-stakeholder discussions that include academic leaders, regulators, drug developers and patients10

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Even modest weight loss (510% of body weight) can lead to significant improvements in cardiovascular risk factors, glycaemic control in type 2 diabetes, sleep apnoea, joint pain, and quality of life