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Remember, the goal is sustainable health, and managing side effects is a vital part of that long-term success

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Stimulant laxatives such as senna and bisacodyl should be used sparingly and only for short-term relief, as regular use can train your colon to depend on them

8 Reasons for less weight loss with GLP1 RAs for T2D could include use of insulin or other obesity-promoting medications, concerns over hypoglycemia, decreased glycosuria, microbiome variation, genetic predisposition towards weight gain, and differences in endogenous GLP-1 pathways in the brain and other tissues

doi: 10.1056/NEJMp2400978 [DOI] [PubMed] [Google Scholar] Associated Data This section collects any data citations, data availability statements, or supplementary materials included in this article.