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Modern research has identified that Specific to its cognitive benefits, berberine[16]: Inhibits A-induced microglia activation Inhibiting the accumulation of A plaques by promoting the synthesis of antioxidant A40 and inhibiting the formation of A42 Decreasing Tau hyperphosphorylation and increasing Tau autophagy clearance Yet another avenue by which berberine supports brain health is by enhancing the gut microbiome.[16,17] Recently published research in Phytomedicine documents that berberine alleviates intestinal inflammation, enhances intestinal permeability, and positively influences the composition and metabolites of the gut microbiota.[17] Animal studies also support many of the health benefits offered by berberine.[16] These potential benefits are in addition to berberines well-known blood sugar support benefits, including[18,19,20]: Upregulating the release of GLP-1 Supporting insulins activity in the body Stimulating brown adipose tissue (BAT) thermogenesis Increasing glycolysis (which supports ATP production) Reducing sugar production in the liver (hepatic gluconeogenesis) Attenuating the breakdown of carbohydrates in the gut Cinnamon Cinnamon is popular cooking and baking spice, commonly added to morning oatmeal and assorted baked treats

Others, including taspoglutide, failed through high incidence of side-effects or insufficient efficacy

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