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The pivotal STEP 1 trial, published in The New England Journal of Medicine in February, included 1,961 adults without diabetes who had obesity or overweight with a weight-related comorbid condition
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Although human data remain limited, early clinical findings suggest increases in beneficial bacteria associated with improved insulin sensitivity
A head-to-head study published in the New England Journal of Medicine in 2025 provides the clearest picture yet
However, most of these events were mild to moderate and temporary
