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Like the index patient, she had multiple overlapping risk factors - adhesive disease, narcotic use, chronic constipation, and prolonged tirzepatide exposure - suggesting a synergistic effect of impaired motility and structural predisposition

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For quantitative analysis [ 18 F]-FDG uptake was measured in whole brain areas, and the standardized uptake value based on body weight (SUV bw ) were calculated

Significant weight loss from retatrutide may alter SHBG levels, shifting free-to-total testosterone ratios and potentially requiring dose adjustments in those on testosterone replacement therapy

Patient Identification We first identified patients with history of kidney stones who were 18 years or older and who had at least 2 encounters 6 months apart in the weight wellness clinic at the University of Texas Southwestern Medical Center between September 2015 and June 2023 (Figure 1)