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Dapagliflozin works at the kidney, and metformin clearance depends partly on kidney function

GLP-1 is primarily produced by enteroendocrine L-cells that are dispersed throughout the small and large intestines

However, the GI side effects (particularly vomiting and diarrhea) can cause dehydration, which hits people with existing kidney disease much harder

The rational design of a potential medium-sized GLP-1RA, such as SR18, described in the current study, opens up the aforementioned avenues for future explorations