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Baseline weight, metabolic status, tolerability, trial design, and treatment duration all shaped how participants responded to different dosages

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According to a subanalysis study of the SURPASS-3 trial, which comparedtirzepatide to insulin degludec, it showed that tirzepatide was associated with a more noticeable reduction in visceral adipose tissue (VAT) and liver fat content [53]

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Tailored dietary programmes, physical activity, glucagon-like peptide 1 receptor agonists and metformin show potential for reducing EOCRC risk, although long-term efficacy and mechanisms require further study