indications for glp 1 agonists The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions Benefits and Risks of GLP-1

10.1016/j.eclinm.2024.102726

Therefore, women of childbearing age should be advised that significant weight loss may increase fertility, requiring effective contraception

This discovery led to the development of exenatide, which in 2005 became the first GLP-1 receptor agonist approved by the FDA for the treatment of type 2 diabetes (T2DM)

G., Gratzl, S., et al

45,46 In contrast, anorexigenic neurons suppress appetite by expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) peptide

56 The most common adverse events were gastrointestinal in the preclinical, phase1 and 2 trials similar to trials involving injectable GLP-1 agonists